Predictors and prognosis of pulmonary hypertension complicating interstitial lung disease in systemic sclerosis

K Morrisroe; D Hansen; W Stevens; L Ross; J Sahhar; GS Ngian; C Hill; L Host; J Walker; S Proudman; M Nikpour

Journal article

Predictors and prognosis of pulmonary hypertension complicating interstitial lung disease in systemic sclerosis

K Morrisroe, D Hansen, W Stevens, L Ross, J Sahhar, GS Ngian, C Hill, L Host, J Walker, S Proudman, M Nikpour

Rheumatology | OXFORD UNIV PRESS | Published : 2025

DOI: 10.1093/rheumatology/keae166

Abstract

Objective: The objective of this study was to identify those SSc patients with concurrent pulmonary hypertension (PH) (SSc-PH patients) and interstitial lung disease (ILD) and determine their disease severity, therapeutic approach, and survival. Methods: Consecutive SSc patients enrolled in the Australian Scleroderma Cohort Study (ASCS) who were diagnosed with pulmonary hypertension (via right-heart catherization) were included in the study. Logistic regression was used to determine the associations of ILD with PH hemodynamic parameters and therapeutic approach. Kaplan–Meier survival curves were used to estimate survival rates. Results: Of 1883 SSc patients, 164 (8.7%) developed incident PH ..

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University of Melbourne Researchers

Katie Morrisroe Author

Wendy Stevens Author

Laura Ross Author

Mandana Nikpour Author

Related Projects (1)

IMPROVING OUTCOMES IN SYSTEMIC AUTOIMMUNE DISEASE

My research is focused on improving outcomes of autoimmune diseases scleroderma and lupus, that can affect multiple organs in the body, caus..

Grants

Awarded by National Health and Medical Research Council of Australia Investigator Grant

Funding Acknowledgements

This work was supported by Scleroderma Australia, Arthritis Australia, Actelion Australia, Bayer, CSL Biotherapies, GlaxoSmithKline Australia and Pfizer. K.M. holds a National Health and Medical Research Council of Australia Investigator Grant (APP1197169). L.R. holds an Arthritis Australia Australian Rheumatology Association-Victoria Fellowship. M.N. holds a National Health and Medical Research Council of Australia Investigator Grant (GTN1176538).